Mycobacterium Tuberculosis

TB Diagnostic Biomarker Discovery Pilot Study

Project Summary

Tuberculosis is a major unresolved Global health challenge presently accounting for more human deaths than any other infectious disease.  Reducing MTB–related mortality will depend on interrupting the transition cycle, which requires improved methods of accurately diagnosing infection and stage of illness.  Current methodologies are inadequate due to problems with test accuracy, and scale ability for widespread use in resource for regions around the world.  MTB infection is associated with complex inflammatory and immunologic changes within the host which track with disease state but remains incompletely explored and defined.  Recent advances in proteomics allowing broad and highly sensitive interrogation of inflammatory markers and low concentrations, and new concepts and serologic diagnosis promise to yield predictive factors that may allow accurate detection of MTB infection and illness staging.  These developments and the availability of a large sample collection from experimentally–infected rhesus macaques and human cohorts offer in parallel with the opportunity to develop candidate diagnostic markers for MTB disease.  We propose a discovery/validation study to capitalize on this opportunity and generate preliminary data for more extensive studies.  This collaboration will involve investigators at Oregon Health & Sciences University/Vaccine and Gene Therapy Institute, and Siriraj Hospital, Mahidol University, Bangkok Thailand

-Photo of one of study leaders, Dr. Kulkanya of SiCRES of Mahidol Univeristy

Opportunities for students include laboratory work at OHSU and cohort work in Thailand